Appetite suppressants claim to help people lose weight. But many people were using them without knowing how they worked.
Many people were doing regular exercise and following a healthy diet to lose weight. But, they struggle to achieve the best results even if they spend more time at the gym or are diligent in counting calories.
Keeping a healthy weight is beneficial in many ways. It reduces the risk of experiencing a heart attack or stroke. It also improves your quality of sleep, energy level, and mobility. It’s important to maintain a healthy weight to prevent the possibility of developing type 2 diabetes.
However, there are instances in which losing weight isn’t an easy task. Working out or doing regular exercise can be tiring and increase the feeling of hunger. This is the reason why many people tend to use appetite suppressants.
Appetite suppressants change the hormonal and chemical processes that make a person feel hungry. Instead, it makes you feel satiated or full for a longer time. Thus, it curbs hunger pangs for emotional or physical satisfaction.
These drugs also boost metabolism, which helps burn more calories. Likewise, a decrease in appetite would mean eating less, thus less calorie intake. Therefore, weight loss is attainable.
Best Appetite Suppressants Supplement
Appetite suppressants are available in different forms. The drugs may differ slightly, but they all work the same way. Here are some of the commonly used appetite suppressants:
1. Phentermine
This appetite suppressant affects the central nervous system. It is taken along with exercise and a proper diet. People having risk factors like diabetes, high cholesterol and high blood pressure can take this drug.
Phentermine is not recommended for those who have a history of severe high blood pressure, glaucoma, overactive thyroid, congestive heart failure and pulmonary hypertension. You should not take this appetite suppressant drug if you are previously to alcohol or drug abuse.
Never take phentermine without consulting your doctor as it shows serious side effects like chest pain, feeling short of breath, swelling of ankles or feet, pounding heartbeats and unusual behaviour or thoughts (1).
You may also experience common side effects, including feeling hyperactive, dizziness, headache, insomnia, dry mouth, upset stomach, constipation or diarrhea and impotence.
2. Phendimetrazine
Phendimetrazine is similar to diethylpropion. It is used as a treatment for obesity, but make sure to consult your doctor first before starting. Taking this drug can be addictive; that’s why you should not use it if it is not prescribed.
This drug shows a dangerous interaction with MAO inhibitor drugs. That’s why you should not take it when you’re using an MAO inhibitor to avoid serious side effects. (2).
It is not recommended if you have a history of heart disease, heart valve disorder, nervousness or severe agitation, glaucoma, or an overactive thyroid. People suffering from kidney disease, diabetes, epilepsy, or anxiety disorder should not take this drug. It is also harmful to an unborn child and even a nursing baby.
Mild side effects of phendimetrazine include feeling restless, dizziness, headache, insomnia, flushing, dry mouth, upset stomach and impotence.
Follow the instructions of your doctor in taking this drug for your safety.
3. Methamphetamine
Methamphetamine is both an appetite suppressant and a stimulant drug. It is commonly available in pill or powder form.
Taking this drug in repeated doses, yet crash or binge pattern. You may experience the “high”, but it starts and fades rapidly. Continuous intake of this drug a few hours after the other can lead to giving up sleep and food.
Methamphetamine directly affects the brain by increasing the amount of dopamine (3). This natural chemical is responsible for body movement, pleasure, reward and motivation. A high level of dopamine in the brain can produce euphoria.
This drug shows short-term effects when taken in small amounts, such as decreased appetite, increased wakefulness, faster breathing, irregular or rapid heartbeat and an increase in body temperature and blood pressure.
People who take methamphetamine through injection are susceptible to infectious diseases like hepatitis B and C, as well as HIV. It may also negatively impact your decision-making and judgment. Thus, it may result in risky behaviours that also increase the risk of acquiring an infection.
Use of this drug can worsen the progression and consequences of HIV or AIDS, which may lead to the development of more cognitive problems.
Long-term use of this drug hurts your health. You may experience extreme weight loss, intense itching, severe dental problems, confusion, anxiety and violent behaviour. Other negative effects include hallucinations and paranoia.
The changes in dopamine can cause impaired verbal learning and reduced coordination. Severe changes can affect the brain function associated with memory and emotion. A study revealed that people who have used this drug can develop Parkinson’s disease in the future.
4. Benzphetamine
Benzphetamine works similarly to amphetamine. It is also an appetite suppressant affecting the central nervous system. Many people have been using this drug to treat obesity along with exercise and a proper diet.
However, this appetite suppressant drug is not recommended for those who have a history of coronary artery disease, uncontrolled or severe high blood pressure, heart disease, glaucoma and overactive thyroid.
Likewise, pregnant women should not take such a drug as it can negatively impact the unborn child. You should also not take benzphetamine if you are a breastfeeding mom, as it can harm your baby.
This drug may show adverse reactions such as shortness of breath, chest pain, pounding heartbeats, irritability or confusion and serious high blood pressure. Common side effects may include sleep problems, dizziness, headache, feeling restless, increased sweating, nausea, dry mouth and skin rash.
To avoid complications or adverse reactions, never take benzphetamine without your doctor’s advice.
5. Diethylpropion
Another appetite suppressant that is used by many people who want to lose weight is diethylpropion. It stimulates the brain and nerves, which increases the blood pressure and heart rate, while it curbs your appetite.
If you are taking an MAO inhibitor, you should not use diethylpropion or have taken other drugs for weight loss. It can lead to life-threatening medical issues when it is taken along with other diet medications.
You should not take this drug if you have a history of or are experiencing pulmonary hypertension, glaucoma, severe coronary artery disease, overactive thyroid, severe high blood pressure and alcohol and drug addiction.
Common side effects of taking this drug include vomiting, nausea, diarrhea, blurred vision and headache, anxiety, dizziness and drowsiness, depressed mood, decreased sex drive and mild itching.
Using this drug more than the prescribed dose can cause serious effects like chest pain, swollen ankles or feet, seizure, uncontrollable muscle movements and sudden weakness or numbness.
Never take this drug if you will drive or need to be alert, as it can cause blurred vision or restlessness. Consult your doctor in case you experience something unusual.
6. Bupropion hydrochloride-naltrexone hydrochloride
This is recommended for overweight people or those facing weight-related medical issues. To achieve the best possible effect, you should take this drug along with behaviour change, a low-calorie diet plan and doctor-approved exercise.
Naltrexone is an opiate antagonist, while bupropion is an antidepressant. These two different medications target separate parts of your brain to control the amount of food you eat and reduce your appetite.
The common side effects of taking this combination of drugs include vomiting, nausea, stomach pain, trouble sleeping, dizziness and increased sweating. You should tell your doctor immediately if you ever encounter any of those side effects.
In serious cases, this drug can cause mood/mental changes, uncontrolled movements, irregular heartbeat and ringing in the ears.
Before taking this appetite suppressant drug, you must first consult your doctor, as it can cause health problems or allergic reactions. Tell your doctor about your medical history, such as high blood pressure, diabetes and heart disease.
This drug isn’t recommended for those with liver and kidney disease, glaucoma or a history of using or abusing alcohol or drugs. You should also not take this medication if you’re taking MAO inhibitors, as it can lead to serious drug interactions.
7. Orlistat
Orlistat is a medication used for weight loss. It blocks fat absorption into your body. To achieve the best result, it should be used along with a low-calorie diet.
This weight loss drug is not recommended for pregnant or breastfeeding women. Likewise, if you are suffering from chronic malabsorption syndrome or have a gallbladder problem, you should avoid taking Orlistat.
It’s also not recommended for people who have diabetes, underactive thyroid, liver disease, pancreatitis or gallstones.
Take Orlistat as prescribed by your doctor for your safety. However, this medication can hinder your body from absorbing vitamins A, D, E and K or the fat-soluble vitamins. Thus, it is recommended to take vitamin supplements while taking Orlistat.
Using an inappropriate amount of Orlistat may cause side effects such as severe lower back pain, blood in the urine, kidney problems and liver problems.
Make sure to buy Orlistat from reliable vendors to avoid getting medications that contain dangerous ingredients.
8. Lorcaserin
Lorcaserin is prescribed for obese or overweight adults. It helps to lose weight and prevent gaining back weight gain. It is categorised as a serotonin receptor agonist. Taking this medication will make you feel full while eating less food.
It is available in tablet form and should be taken twice a day. Make sure to follow the instructions of your doctor. It can be addictive, that’s why you should not take it longer than prescribed.
Possible side effects of using Lorcaserin include constipation, excessive tiredness, back and muscle pain, dizziness, headache, insomnia, anxiety, problems with urination and blurred vision. You must seek a doctor’s advice if the symptoms get worse.
Are Appetite Suppressants Right For You?
Weight gain increases the risk of developing serious health issues or complications. This is the reason why it is important to lose weight. But, it’s not easy to lose weight even if you’re doing exercise or following a healthy diet plan. Thus, many people tend to use appetite suppressants.
Before you try using this weight loss medication, you must first know if it is right for you. There are several factors that you need to consider, including the following:
- Medical history
Before taking appetite suppressants, you must ensure that you’re not taking any prescriptions. This makes sense of letting your doctor assess your medical history. You should provide all the necessary information regarding your medical condition as well as the medications that you’re taking.
- Weight loss issues
Appetite suppressants are given to dieters who find difficulty in their weight loss journey. There are instances in which losing weight fails due to food cravings or hunger pangs. Taking suppressants makes you feel full for a longer time.
Aside from taking appetite suppressants, you must ensure you take proper nutrition to achieve your goals of losing weight.
What Are The Side Effects Of Appetite Suppressants?
Appetite suppressants, whether prescription drugs, over-the-counter pills, or natural remedies, can cause side effects depending on what you’re taking, how much, and your body’s reaction. Here’s a straightforward rundown of what you might experience.
Prescription Appetite Suppressants (like Phentermine, Liraglutide, or Naltrexone-Bupropion)
These are doctor-prescribed for weight loss and can have noticeable effects:
Common Issues:
- Dry mouth
- Trouble sleeping
- Faster heartbeat or higher blood pressure
- Feeling nervous, anxious, or irritable
- Headaches
- Dizziness
- Constipation or diarrhea
- Nausea or vomiting
Serious Problems (rare, but get help right away):
- Heart palpitations or chest pain
- Trouble breathing
- Extreme mood changes (like depression or agitation)
- Signs of lung issues (very rare, but serious)
- Risk of dependence or withdrawal with some drugs (like phentermine)
- Allergic reactions (rash, swelling, breathing problems)
- Over-the-Counter Pills (like ones with Caffeine, Garcinia Cambogia, or Hoodia)
- These are sold as weight-loss supplements and aren’t always tightly regulated:
Common Issues:
- Feeling jittery or restless (especially with caffeine)
- Stomach upset or digestion problems
- Faster heart rate
- Headaches
- Trouble sleeping
Possible Risks:
- Can mess with other medications (like caffeine with stimulants)
- Some don’t work well or at all for weight loss
- Rarely, liver problems (like with high doses of green tea extract)
- Allergic reactions to herbal ingredients
Natural or Herbal Options (like Glucomannan, Green Tea Extract, or Fenugreek)
These seem safer but still have downsides:
Common Issues:
- Bloating, gas, or stomach discomfort (especially with fibre-based ones like glucomannan)
- Mild nausea
- Headaches
- Allergic reactions to herbs
Possible Risks:
- Choking or throat blockage if fibre pills aren’t taken with enough water
- Can interfere with medicines (like green tea extract with blood thinners)
- Not much proof they’re safe or effective long-term
FAQ About Appetite Suppressant Supplements for Weight Loss
1. What are appetite suppressant supplements?
These are pills, powders, or natural remedies that help you feel less hungry or feel full quicker, so you eat less and lose weight. They can be prescription drugs, over-the-counter (OTC) products, or natural substances like fibre or herbs.
2. How do they work?
It depends on the type. Some mess with brain chemicals to curb hunger. Others, like fibre supplements, fill up your stomach to make you feel satisfied. Some might speed up your metabolism or stop your body from absorbing fat.
3. Are they safe?
It depends on the supplement and your health. Prescription ones are usually okay with a doctor’s guidance, but can cause things like a racing heart or trouble sleeping. OTC and natural ones aren’t always tightly regulated, so quality and safety can be iffy. Talk to a doctor, especially if you have health issues or take other meds.
4. How Much Weight Will You Lose With Appetite Suppressants?
Health experts revealed that when taking appetite suppressants, the expected average weight loss is no more than 10% of your body’s current weight.
However, studies also showed that after six months of using appetite suppressants, they are not effective anymore.
Usually, you should expect weight regain after you stop taking it. That’s why you must learn and practice healthy eating habits and exercise regularly.
If you think that your health is in peril due to being overweight or obese, the best thing to do is to seek help from your healthcare provider. Although appetite suppressants help to lose weight effectively, you must be very careful in choosing the right one that will work best for your weight loss needs.
However, these appetite suppressants are not substituting for a healthy diet and exercise to keep your body trim and healthy.
5. Can I use them for a long time?
Prescription ones are usually for short-term use (a few weeks or months) because of risks like dependence or heart issues. Natural or OTC ones might be okay longer, but there’s little evidence they’re safe for years. Check with a doctor if you want to keep using them.
6. Do they work for everyone?
Not always. Some people shed pounds, others don’t notice much. They work best when you pair them with a healthy diet and exercise. Things like your genes, lifestyle, or health conditions can change how well they work.
7. Can I mix them with other medications?
They might not play nice with drugs like antidepressants, blood pressure meds, or diabetes treatments, which could cause problems. Tell your doctor about everything you’re taking to avoid any potential issues.
8. Are natural ones better than prescription ones?
Natural options (like glucomannan or green tea extract) might have fewer side effects for some, but there’s not always solid proof they work. Prescription ones are better studied and stronger, but need a doctor’s oversight because they’re riskier. It depends on what you need and your health.
9. Do I need a prescription?
Some, like phentermine or liraglutide, need a doctor’s prescription because they’re strong. OTC stuff (like supplements with caffeine or garcinia cambogia) and natural remedies don’t, but you should still be careful.
10. How do I get the best results?
To make them work better:
Eat a healthy, low-calorie diet.
Stay active with exercise.
Drink lots of water, especially with fibre supplements.
Stick to the recommended dose.
Team up with a doctor or dietitian for a solid weight loss plan.
Heads-up: Talk to a doctor before trying any appetite suppressant to make sure it’s safe for you. Got questions about a specific one? Ask your doctor or let me know, and I can dig deeper!
is a registered dietitian with over 10 years of experience in the field of nutrition. She has a Master’s degree in Nutritional Science from Dhaka University and has worked with various clients to help them achieve their health goals through personalized diet plans. Mounota is passionate about educating people on the benefits of a healthy diet and lifestyle and has written extensively on the subject for various publications.
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